Article
A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis.
The Journal of allergy and clinical immunology - 1 Sept 2024
Hernandez-Cordero Ariana, Thomas Laurent, Smail Alice, Lim Zhao Qin, Saklatvala Jake R, Chung Raymond, Curtis Charles J, Baum Patrick, Visvanathan Sudha, Burden A David, Cooper Hywel L, Dunnill Giles, Griffiths Christopher E M, Levell Nick J, Parslew Richard, Reynolds Nick J, Wahie Shyamal, Warren Richard B, Wright Andrew, Simpson Michael, Hveem Kristian, Barker Jonathan N, Dand Nick, Løset Mari, Smith Catherine H, Capon Francesca
Abstract excerpt
BACKGROUND: Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manifests with painful pustular eruptions on the palms and soles. Although the disease can present with concurrent plaque psoriasis, TNF and IL-17/IL-23 inhibitors show limited efficacy. There is therefore a pressing need to uncover PPP disease drivers and therapeutic targets. OBJECTIVES: We sought to...
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