Article

Activation of the Anaphase Promoting Complex Restores Impaired Mitotic Progression and Chemosensitivity in Multiple Drug Resistant Human Breast Cancer

2024-03-28

Abstract excerpt

The development of multiple drug resistant (MDR) cancer all too often signals the need for alternative toxic therapy or palliative care. Our recent in vivo and in vitro studies using canine MDR lymphoma cancer cells demonstrated that the Anaphase Promoting Complex (APC) is impaired in MDR cells compared to normal canine control and drug sensitive cancer cells. Here, we sought to establish whether this phenomena is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88734f73-bed1-521b-a248-7000c243655e
DOI: 10.20944/preprints202403.1579.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the Anaphase Promoting Complex Restores Impaired Mitotic Progression and Chemosensitivity in Multiple Drug Resistant Human Breast CancerDOI 10.20944/preprints202403.1579.v2Read

Activation of the Anaphase Promoting Complex reverses multiple drug resistant cancerSemantic proximity Read

Activation of the Anaphase Promoting Complex Reverses Multiple Drug Resistant Cancer in a Canine Model of Multiple Drug Resistant LymphomaSemantic proximity Read

ATR and PKMYT1 inhibition re-sensitize a subset of TNBC patient-derived models to carboplatin inducing mitotic catastropheSemantic proximity Read

Mitotic slippage: an old tale with a new twistSemantic proximity Read

Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours: Part 1. Proliferation, apoptosis and DNA repairSemantic proximity Read

Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cellsSemantic proximity Read

Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic deathSemantic proximity Read

APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cellsSemantic proximity Read

Phenotype-rescue of cyclin-dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer.Semantic proximity Read

Adenomatous Polyposis Coli Loss Controls Cell Cycle Regulators and Response to PaclitaxelSemantic proximity Read

Curcumin Affects Components of the Chromosomal Passenger Complex and Induces Mitotic Catastrophe in Apoptosis-Resistant Bcr-Abl-Expressing CellsSemantic proximity Read

Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosisSemantic proximity Read