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APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells

20 Nov 2019

Abstract excerpt

Chemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known breast cancer receptors used for targeted therapy, is reliant on chemotherapy as the standard of care. The Adenomatous Polyposis Coli ( APC ) tumor suppressor is mutated or hypermethylated in 70% of sporadic breast cancers with APC-deficient tumors...

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Identifiers

PMID: 31759252
DOI: 10.1016/j.neo.2019.09.002

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