Article

Activation of the Anaphase Promoting Complex reverses multiple drug resistant cancer

2020-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Like humans, canines spontaneously develop lymphomas that are treated by chemotherapy cocktails and frequently develop multiple drug resistance (MDR). Their shortened clinical timelines and tumor accessibility make them excellent models to study MDR mechanisms. We previously demonstrated that adjunct treatment of in vitro MDR cell lines with insulin-sensitizers effectively restored MDR chemosen...

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Literature Corpus work: 1a364cf0-9a28-521d-b391-0d3ae23c1f69
DOI: 10.1101/2020.05.26.115337

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