Article

Inheritance entropy quantifies epigenetic regulation of cell-cycle exit in human bone marrow stromal cells

2025-10-22

Abstract excerpt

Human bone marrow stromal cells (BMSC) include skeletal stem cells with ground-breaking the-rapeutic potential. However, BMSC colonies have very heterogeneous in vivo behaviour, due to their different potency; this unpredictability is the greatest hurdle to the development of skeletal regeneration therapies. Colony-level heterogeneity urges a fundamental question: how is it possible that one colony as a collective...

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Literature Corpus work: 8872673f-1c95-55c0-99fa-c14219ad11f1
DOI: 10.1101/2025.10.21.683667

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