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The role of Matrin-3 in physiology and its dysregulation in disease

30 May 2024

Abstract excerpt

The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These proteins serve many important roles in the cell, and their capacity to form biomolecular condensates (BMCs) is key to their function, but also a vulnerability that can lead to misregulation and disease. Matrin-3...

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PMID: 38813817
DOI: 10.1042/bst20220585

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