Article

A virus-induced molecular mimicry model of multiple sclerosis

2001-07-15

Abstract excerpt

Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the neurotropic picornavirus Theiler’s murine encephalomyelitis virus (TMEV) leads to a progressive CD4+ T cell–mediated demyelinating disease similar to multiple sclerosis. To study the potential of virus-induced molecular mimicry to initiate autoimmune demyelination...

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Literature Corpus work: 88649ccf-36ff-540a-9c56-2393cc6f9dd3
DOI: 10.1172/jci200113032

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