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A virus-induced molecular mimicry model of multiple sclerosis

15 Jul 2001

Abstract excerpt

Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the neurotropic picornavirus Theiler's murine encephalomyelitis virus (TMEV) leads to a progressive CD4(+) T cell-mediated demyelinating disease similar to multiple sclerosis. To study the potential of virus-induced molecular mimicry to initiate autoimmune...

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PMID: 11457884
DOI: 10.1172/jci13032

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