Article

Interpreting Mendelian randomization estimates of the effects of categorical exposures such as disease status and educational attainment

2020-12-14

Abstract excerpt

Mendelian randomization has been previously used to estimate the effects of binary and ordinal categorical exposures - e.g. type 2 diabetes or educational attainment defined by qualification - on outcomes. Binary and categorical phenotypes can be modelled in terms of liability, an underlying latent continuous variable with liability thresholds separating individuals into categories. Genetic variants typically infl...

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Literature Corpus work: 8853709a-f4ec-58a6-bc96-efe7eb49c757
DOI: 10.1101/2020.12.14.20248168

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