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Article

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study.

International journal of epidemiology - 5 Oct 2023

Howe Laurence J, Rasheed Humaira, Jones Paul R, Boomsma Dorret I, Evans David M, Giannelis Alexandros, Hayward Caroline, Hopper John L, Hughes Amanda, Lahtinen Hannu, Li Shuai, Lind Penelope A, Martin Nicholas G, Martikainen Pekka, Medland Sarah E, Morris Tim T, Nivard Michel G, Pingault Jean-Baptiste, Silventoinen Karri, Smith Jennifer A, Willoughby Emily A, Wilson James F, Åsvold Bjørn Olav, Næss Øyvind E, Davey Smith George, Kaprio Jaakko, Brumpton Ben, Davies Neil M

Abstract excerpt

BACKGROUND: Previous Mendelian randomization (MR) studies using population samples (population MR) have provided evidence for beneficial effects of educational attainment on health outcomes in adulthood. However, estimates from these studies may have been susceptible to bias from population stratification, assortative mating and indirect genetic effects due to unadjusted parental genotypes. MR using genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37295953
DOI: 10.1093/ije/dyad079
PMCID: PMC10555788

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