Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression.

doi:10.1096/fj.06-7285com

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Article

Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2007

Pescatori Mario, Broccolini Aldobrando, Minetti Carlo, Bertini Enrico, Bruno Claudio, D'amico Adele, Bernardini Camilla, Mirabella Massimiliano, Silvestri Gabriella, Giglio Vincenzo, Modoni Anna, Pedemonte Marina, Tasca Giorgio, Galluzzi Giuliana, Mercuri Eugenio, Tonali Pietro A, Ricci Enzo

Abstract excerpt

Genome-wide gene expression profiling of skeletal muscle from Duchenne muscular dystrophy (DMD) patients has been used to describe muscle tissue alterations in DMD children older than 5 years. By studying the expression profile of 19 patients younger than 2 years, we describe with high resolution the gene expression signature that characterizes DMD muscle during the initial or "presymptomatic" phase of the...

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PMID: 17264171
DOI: 10.1096/fj.06-7285com

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