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Exploring the mechanisms governing the initiation of plexiform neurofibromas using <i>Prss56</i> <sup>Cre</sup> , <i>Nf1</i> -KO mouse model at a single-cell resolution

2025-07-07

Abstract excerpt

About half of patients with the genetic disease Neurofibromatosis type 1 (NF1) develop benign nerve sheath tumors, called plexiform neurofibromas (pNFs). Despite important advances in understanding the pathogenesis of pNFs, mainly due to the plethora of dedicated mouse models, the mechanisms responsible for the initiation of this process remain poorly understood. Here, we used a Nf1 -KO mouse model targeting bial...

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Literature Corpus work
87f3405e-e767-51c1-91f1-2ea1ebad20ad
DOI
10.1101/2025.07.04.662123
Open publication

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Exploring the mechanisms governing the initiation of plexiform neurofibromas using <i>Prss56</i> <sup>Cre</sup> , <i>Nf1</i> -KO mouse model at a single-cell resolutionDOI 10.1101/2025.07.04.662123
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