Article

Inferring sparse structure in genotype-phenotype maps

2022-09-27

Abstract excerpt

Correlation among multiple phenotypes across related individuals may reflect some pattern of shared genetic architecture: individual genetic loci affect multiple phenotypes (an effect known as pleiotropy), creating observable relationships between phenotypes. A natural hypothesis is that pleiotropic effects reflect a relatively small set of common “core” cellular processes: each genetic locus affects one or a few...

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Literature Corpus work: 87b2acc9-c76e-572c-8296-1bd2aa58f04b
DOI: 10.1101/2022.09.27.509675

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