Article
Joint genetic analysis of gene expression data with inferred cellular phenotypes.
PLoS genetics - 20 Jan 2011
Parts Leopold, Stegle Oliver, Winn John, Durbin Richard
Abstract excerpt
Even within a defined cell type, the expression level of a gene differs in individual samples. The effects of genotype, measured factors such as environmental conditions, and their interactions have been explored in recent studies. Methods have also been developed to identify unmeasured intermediate factors that coherently influence transcript levels of multiple genes. Here, we show how to bring these two...
Topics
- Algorithms
- Biosynthetic Pathways
- Data Interpretation, Statistical
- Databases, Protein
- Environment
- Epistasis, Genetic
- Gene Expression
- Gene Regulatory Networks
- Genetic Association Studies
- Genetic Variation
- Genotype