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Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation

23 Jan 2012

Abstract excerpt

The cilium serves as a cellular antenna by coordinating upstream environmental cues with numerous downstream signaling processes that are indispensable for the function of the cell. This role is supported by the revelation that defects of the cilium underlie an emerging class of human disorders, termed "ciliopathies." Although mounting interest in the cilium has demonstrated the essential role that the organelle...

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PMID: 22308353
DOI: 10.1073/pnas.1112834109

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