Article

Network nature of ligand-receptor interactions underlies disease comorbidity in the brain

2024-06-16

Abstract excerpt

Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk genes. We have investigated whether ligand-receptor interactions (LRIs) are a mechanism by which distinct genes associated with disease risk can impact overlapping outcomes. We found that LRIs are likely disrupted in neurological disease and that the ligand-receptor networks associat...

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Literature Corpus work: 8792aee8-4eef-564b-b076-d342f6db5489
DOI: 10.1101/2024.06.15.599140

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