Article

Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1

2025-04-21

Abstract excerpt

<title>Abstract</title> <p>Background Tumors often evade immune surveillance by limiting T cell infiltration. In non-small cell lung cancer (NSCLC), increased infiltration of CD8<sup>+</sup> T cells is associated with a favorable response to immunotherapy. While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified. Methods To invest...

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Literature Corpus work: 877c5858-c1a3-522b-8602-34738ae6c39d
DOI: 10.21203/rs.3.rs-5907029/v1

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Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1DOI 10.21203/rs.3.rs-5907029/v1Read

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