Article

A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels of antigen express unique transcriptional programs. We used single cell sequencing in dissociated LN tissue and spatial transcriptomics to quantify antigen levels in LEC subsets and den...

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Literature Corpus work: 87734115-0daa-5eac-95d2-ab8906f5b3f4
DOI: 10.21203/rs.3.rs-5493746/v1

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