Article

The local and systemic response to SARS-CoV-2 infection in children and adults

2021-03-15

Abstract excerpt

While a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. Therefore, understanding differences in the local and systemic response to SARS-CoV-2 infection between children and adults may provide important clues about the pathogenesis of SARS-CoV-2 infection. To address this, we first generated a healthy reference multi-o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7d395c3-0d87-527d-bfc2-b4d588aac35d
DOI: 10.1101/2021.03.09.21253012

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The local and systemic response to SARS-CoV-2 infection in children and adultsDOI 10.1101/2021.03.09.21253012Read

Immune perturbations induced by SARS-CoV2 in infants vary with disease severity and differ from adults’ responsesSemantic proximity Read

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19Semantic proximity Read

Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infectionsSemantic proximity Read

Differential host responses within the upper respiratory tract and peripheral blood of children and adults with SARS-CoV-2 infectionSemantic proximity Read

Unique nasal cell states induced by common pediatric respiratory virusesSemantic proximity Read

Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infectionsSemantic proximity Read

Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of lifeSemantic proximity Read

Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infectionSemantic proximity Read

Innate lymphoid cells and disease tolerance in SARS-CoV-2 infectionSemantic proximity Read

Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cellsSemantic proximity Read

Immune response to SARS-CoV-2 in the nasal mucosa in children and adultsSemantic proximity Read

Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adultsSemantic proximity Read