Article

Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation

2019-03-22

Abstract excerpt

<h4>ABSTRACT</h4> A comprehensive reference map of all cell types in the human body is necessary for improving our understanding of fundamental biological processes and in diagnosing and treating disease. High-throughput single-cell RNA sequencing techniques have emerged as powerful tools to identify and characterize cell types in complex and heterogeneous tissues. However, extracting intact cells from tissues an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 873708cc-2601-56ba-b43f-dc7c8a58e389
DOI: 10.1101/585901

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte DifferentiationDOI 10.1101/585901Read

Advancing Nuclei Isolation from Frozen Human Heart for Single-Nucleus RNA Sequencing ApplicationsSemantic proximity Read

Transcriptional and Cellular Diversity of the Human HeartSemantic proximity Read

Correlation of gene expressions between nucleus and cytoplasm reflects single-cell physiologySemantic proximity Read

Single cell transcriptomic analyses of human heart failure with preserved ejection fractionSemantic proximity Read

QClus: A droplet-filtering algorithm for enhanced snRNA-seq data quality in challenging samplesSemantic proximity Read

Cell fixation and preservation for droplet-based single-cell transcriptomicsSemantic proximity Read

A Method for Cryopreservation and Single Nucleus RNA-sequencing of Normal Adult Human Interventricular Septum Heart Tissue Reveals Cellular Diversity and FunctionSemantic proximity Read

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failureSemantic proximity Read

Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human heartsSemantic proximity Read

<i>LMNA</i> -Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C HaploinsufficiencySemantic proximity Read

HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and DiseaseSemantic proximity Read

Large particle fluorescence-activated cell sorting enables high quality single cell RNA-sequencing and functional analysis of adult cardiomyocytesSemantic proximity Read