Article

QClus: A droplet-filtering algorithm for enhanced snRNA-seq data quality in challenging samples

2022-10-22

Abstract excerpt

Single nuclei RNA sequencing (snRNA-seq) remains a challenge for many human tissues, as incomplete removal of background signal masks cell-type-specific signals and interferes with downstream analyses. Here, we present QClus, a droplet-filtering algorithm targeted toward challenging samples, using cardiac tissue as an example. QClus uses specific metrics such as cell-type-specific marker gene expression to cluster...

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Literature Corpus work: 684c52ee-9647-5e5e-b2bc-124840aa1b94
DOI: 10.1101/2022.10.21.513315

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