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IPF-related new macrophage subpopulations and diagnostic biomarker identification - combine machine learning with single-cell analysis

13 Jun 2024

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown etiology that lacks a specific treatment. In IPF, macrophages play a key regulatory role as a major component of the lung immune system, especially during inflammation and fibrosis. However, our understanding of the cellular heterogeneity and molecular characterization of macrophages in IPF, as well as their relevance in the clinical setting, is...

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PMID: 38872139
DOI: 10.1186/s12931-024-02845-8

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