Article

Stochasticity and order : studies of keratinocyte proliferation

2014-01-01

Abstract excerpt

A central tenet of stem cell biology has been that proliferating tissues are maintained through a cellular hierarchy comprising of self-renewing stem cells at the apex, multiple lineage-restricted short-lived progenitor cells, and post-mitotic differentiated cells. The wide range of colony sizes in cultured human keratinocytes has been taken to support this hypothesis. Contrary to this model, researchers using gen...

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Literature Corpus work: 871314d3-0766-583f-86bd-b98255745f6c
DOI: 10.17863/cam.16511

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