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Article

Human keratinocytes have two interconvertible modes of proliferation.

Nature cell biology - 1 Feb 2016

Roshan Amit, Murai Kasumi, Fowler Joanna, Simons Benjamin D, Nikolaidou-Neokosmidou Varvara, Jones Philip H

Abstract excerpt

Single stem cells, including those in human epidermis, have a remarkable ability to reconstitute tissues in vitro, but the cellular mechanisms that enable this are ill-defined. Here we used live imaging to track the outcome of thousands of divisions in clonal cultures of primary human epidermal keratinocytes. Two modes of proliferation were seen. In 'balanced' mode, similar proportions of proliferating and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26641719
DOI: 10.1038/ncb3282
PMCID: PMC4872834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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