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Article

Actin filament dynamics impacts keratinocyte stem cell maintenance

1 Apr 2013

Abstract excerpt

Cultured human epidermal keratinocyte stem cells (holoclones) are crucial for regenerative medicine for burns and genetic disorders. In serial culture, holoclones progressively lose their proliferative capacity to become transient amplifying cells with limited growth (paraclones), a phenomenon termed clonal conversion. Although it negatively impacts the culture lifespan and the success of cell transplantation,...

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PMID: 23554171
DOI: 10.1002/emmm.201201839

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