Article

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

2025-10-16

Abstract excerpt

Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cancer have failed to elicit durable clinical responses. PCa progression is driven by transcriptional networks regulated by key transcription factors including the androgen receptor (AR) and the oncogene MYC. How this cros...

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Literature Corpus work: 86f0a3ad-c823-546f-8248-1366d49eb237
DOI: 10.1101/2025.10.15.682547

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