Article
Tumor Fusion Burden as a Hallmark of Immune Infiltration in Prostate Cancer.
Cancer immunology research - 1 Jul 2020
Wagle Marie-Claire, Castillo Joseph, Srinivasan Shrividhya, Holcomb Thomas, Yuen Kobe C, Kadel Edward E, Mariathasan Sanjeev, Halligan Daniel L, Carr Adrian R, Bylesjo Max, McAdam Paul R, Lynagh Sarah, Marien Koen M, Kockx Mark, Waumans Yannick, Huang Shih-Min A, Lackner Mark R, Mounir Zineb
Abstract excerpt
Prostate cancer is the second leading cause of cancer-related death in men. Despite having a relatively lower tumor mutational burden than most tumor types, multiple gene fusions such as TMPRSS2:ERG have been characterized and linked to more aggressive disease. Individual tumor samples have been found to contain multiple fusions, and it remains unknown whether these fusions increase tumor immunogenicity. Here, we...
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