Article

Membrane-active peptides escape drug-resistance in cancer

2022-10-28

Abstract excerpt

Acquired drug-resistance is a recurring problem in cancer treatment, and this is particularly true for patients with metastatic melanoma that carry a BRAF V600E mutation. In the current study, we explored the use of membrane-active peptides as an alternative therapeutic modality to target drug-resistant melanoma cells. We produced slow-cycling and drug-resistant melanoma cells using dabrafenib, a small molecule dr...

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Literature Corpus work: 86a7f3aa-398b-5a4b-aa5e-961a5b4bba24
DOI: 10.1101/2022.10.27.513961

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