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On the development of B-Raf inhibitors acting through innovative mechanisms

2022-04-26

Abstract excerpt

B-Raf is a protein kinase participating to the regulation of many biological processes in cells. Several studies have demonstrated that this protein is frequently upregulated in human cancers, especially when it bears activating mutations. In the last years, few ATP-competitive inhibitors of B-Raf have been marketed for the treatment of melanoma and are currently under clinical evaluation on a variety of other typ...

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Literature Corpus work
bb5f6e72-45c4-51b8-adc5-c17310ac25f6
DOI
10.12688/f1000research.108761.2
Open publication

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On the development of B-Raf inhibitors acting through innovative mechanismsDOI 10.12688/f1000research.108761.2
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