Article

Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

2023-11-16

Abstract excerpt

Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, such as exophers produced by proteostressed C. elegans touch neurons, are poorly understood. Here we document that mechanical force can significantly potentiate exopher extrusion...

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Literature Corpus work: 85d4586f-0739-548b-aaec-97ff5488640b
DOI: 10.1101/2023.11.13.565361

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