Article

Hesperetin blocks poxvirus replication by competitively inhibiting binding of the 5' cap of viral mRNA with eIF4E

2023-09-22

Abstract excerpt

In this study, hesperetin was shown to inhibit the replication of multiple poxviruses, including buffalopox virus (BPXV), vaccinia virus, and lumpy skin disease virus (LSDV). Hesperetin mainly suppressed viral protein synthesis without affecting other steps of the viral life cycle such as attachment, entry, and budding. In a chromatin immunoprecipitation (CHIP) assay, we further demonstrated that hesperetin-induce...

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Literature Corpus work: 85d245f7-cff0-5e93-9e47-8d329dc01777
DOI: 10.22541/au.169536436.65716308/v1

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