Article

HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability

2025-10-14

Abstract excerpt

Post-stroke epilepsy (PSE) is a leading cause of acquired epilepsy in adults, yet the molecular mechanisms linking post-ischemic hypoxia to neuronal hyperexcitability remain poorly understood. The transcription factor hypoxia-inducible factor 1α (HIF1α) is a central mediator of the cellular response to hypoxia and may contribute to epileptogenesis by regulating ion channel expression. Here, we identify the T-type...

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Literature Corpus work: 8566c14a-4144-5fbe-961b-6ec632d0e9de
DOI: 10.1101/2025.10.13.682038

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HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitabilityDOI 10.1101/2025.10.13.682038Read

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