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Article

Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression.

Molecular cancer research : MCR - 1 Sept 2021

Alzofon Nathaniel, Koc Katrina, Panwell Kristin, Pozdeyev Nikita, Marshall Carrie B, Albuja-Cruz Maria, Raeburn Christopher D, Nathanson Katherine L, Cohen Debbie L, Wierman Margaret E, Kiseljak-Vassiliades Katja, Fishbein Lauren

Abstract excerpt

Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associated with aggressive disease. Here, we aimed to investigate the role of MAML3 in tumorigenesis. Human PCC/PGLs were used for IHC and genetic analysis. Three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33986121
DOI: 10.1158/1541-7786.MCR-20-0992
PMCID: PMC8419063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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