Article

METTL14-dependent m 6 A modification of circUGGT2 drives gastric cancer progression by sponging miR-186-3p and upregulating MAP3K9

2023-03-29

Abstract excerpt

<h4>Background: </h4> N6-methyladenosine (m 6 A) RNA modification has been shown to act fundamental roles in cancer progression. However, the underlying mechanisms by which m 6 A modification of circRNAs contributes to gastric cancer (GC) remain unknown. <h4>Methods: </h4>: METTL14-mediated m 6 A modification of circRNAs was identified by an m 6 A-circRNA epi-transcriptomic microarray and verified by methylated R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84d91fe0-4b36-5de7-bea5-563657fd65e9
DOI: 10.21203/rs.3.rs-2737082/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

METTL14-dependent m 6 A modification of circUGGT2 drives gastric cancer progression by sponging miR-186-3p and upregulating MAP3K9DOI 10.21203/rs.3.rs-2737082/v1Read

METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinomaSemantic proximity Read

N6-methyladenosine demethylase FTO serves as an indicator for predicting prognosis and immunotherapy response in individuals with gastric cancerSemantic proximity Read

CircPTK2 Inhibits the Tumorigenesis and Metastasis of Gastric Cancer by Sponging miR-134-5p and Activating CELF2/PTEN SignalingSemantic proximity Read

N6-methyladenosine modification of circular RNA circASH2L suppresses growth and metastasis in hepatocellular carcinoma through regulating hsa-miR-525-3p/MTUS2 axisSemantic proximity Read

CircMTDH promotes the development of gastric cancer and the mechanismSemantic proximity Read

Down-regulation of circular RNAITCH and circHIPK3 in gastric cancer tissuesSemantic proximity Read

N 6 -methyladenosine (m 6 A) RNA methylation signature as a predictor of stomach adenocarcinoma outcomes and its association with immune checkpoint moleculesSemantic proximity Read

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancerSemantic proximity Read

The m6A demethylase FTO promotes esophageal cancer progression via the YTHDF1/AKT3 signaling networkSemantic proximity Read

High-throughput sequencing reveals the epitranscriptome-wide landscape of m6A-modified circRNA in oral squamous cell carcinomaSemantic proximity Read

Epigenetic Regulation of m6A Modifications in Human CancerSemantic proximity Read

Identification of seven circRNAs that are repeatedly down-regulated in gastric cancer as a biomarker and their potential miRNA targetsSemantic proximity Read