Article

Telomerase-independence function of Dyskerin is therapeutic vulnerability in p53 mutant pancreatic neuroendocrine tumors

2023-07-10

Abstract excerpt

<title>Abstract</title> <p>Pancreatic neuroendocrine tumors (PanNETs) use the recombination-mediated alternative lengthening of telomeres (ALT) mechanism, instead of telomerase, for telomere maintenance, while the relationship between this mechanism and clinical practice is still unknown, especially chemotherapy resistance. Here, we found Temozolomide (TMZ) activated the RNA-binding protein dyskerin, encoded by D...

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Literature Corpus work: 84d7f138-3034-5123-8106-e314c399371b
DOI: 10.21203/rs.3.rs-3013455/v1

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