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Article

<i>MYC</i> -Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

14 Apr 2016

Abstract excerpt

The RNA-binding protein dyskerin, encoded by the DKC1 gene, functions as a core component of the telomerase holoenzyme as well as ribonuclear protein complexes involved in RNA processing and ribosome biogenesis. The diverse roles of dyskerin across many facets of RNA biology implicate its potential contribution to malignancy. In this study, we examined the expression and function of dyskerin in neuroblastoma. We...

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PMID: 27197171
DOI: 10.1158/0008-5472.can-15-0879

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<i>MYC</i> -Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of DyskerinPMID 27197171Read ↗

DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland CellsSemantic proximity Read ↗

Dyskerin is required for tumor cell growth through mechanisms that are independent of its role in telomerase and only partially related to its function in precursor rRNA processingSemantic proximity Read ↗

Telomerase-independence function of Dyskerin is therapeutic vulnerability in p53 mutant pancreatic neuroendocrine tumorsSemantic proximity Read ↗

Dyskerin Overexpression in Human Hepatocellular Carcinoma Is Associated with Advanced Clinical Stage and Poor Patient PrognosisSemantic proximity Read ↗

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastomaSemantic proximity Read ↗

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.Semantic proximity Read ↗

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblastsSemantic proximity Read ↗

Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer.Semantic proximity Read ↗

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibitionSemantic proximity Read ↗

VRK1 kinase maintains an undifferentiated proliferative state in neuroblastoma tumor cellsSemantic proximity Read ↗

snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor PrognosisSemantic proximity Read ↗

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA TranslationSemantic proximity Read ↗

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