MMP-2 protein in invasive breast cancer and the impact of MMP-2/TIMP-2 phenotype on overall survival.

doi:10.1023/a:1021371028777

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Article

MMP-2 protein in invasive breast cancer and the impact of MMP-2/TIMP-2 phenotype on overall survival.

Breast cancer research and treatment - 1 Jan 2003

Nakopoulou Lydia, Tsirmpa Ioanna, Alexandrou Paraskevi, Louvrou Androniki, Ampela Constantine, Markaki Sophia, Davaris Panayiotis S

Abstract excerpt

Crucial event in the metastasis of cancer cells is the secretion of matrix metalloproteinases (MMPs), which are responsible for the degradation of extracellular matrix (ECM). Among them, matrix metalloproteinase-2 (MMP-2) is a gelatinase, which degrades basement membrane type-IV collagen. Immunohistochemistry was performed to detect MMP-2 protein in 135 infiltrative breast carcinomas. MMP-2 was studied along with...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Female
Humans
Immunohistochemistry
Ki-67 Antigen
Matrix Metalloproteinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Neoplasm Invasiveness

Neoplasm Metastasis

Neoplasm Staging

Phenotype

Survival Analysis

Tissue Inhibitor of Metalloproteinase-2

Source

Open in PubMed

Identifiers

PMID: 12602913
DOI: 10.1023/a:1021371028777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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