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Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomas

2025-12-31

Abstract excerpt

Canine osteosarcoma (OS) is an aggressive bone cancer with remarkable similarity to human OS. Despite its value as a comparative oncology model, the drivers of genomic instability remain poorly defined, hindering cross-species insights into disease progression. We applied long-read PacBio HiFi whole genome sequencing to matched tumor and blood samples from four purebred dogs to generate high-resolution maps of som...

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Literature Corpus work
847ed8cc-aaf4-5da5-a678-1aabca45981e
DOI
10.64898/2025.12.31.697157
Open publication

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Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomasDOI 10.64898/2025.12.31.697157
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