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Bone Loss is Ameliorated by Fecal Microbiota Transplantation through SCFA/GPR41/ IGF1 Pathway in Sickle Cell Disease Mice

2022-07-07

Abstract excerpt

Bone loss is common in sickle cell disease (SCD), but the molecular mechanisms is unclear. Serum insulin-like growth factor 1 (IGF1) was low in SCD subjects and SCD mice. To determine if decreased IGF1 associated with low bone mass in SCD is due to reduced SCFA production by gut microbiota, we performed reciprocal fecal microbiota transplantation (FMT) between healthy control (Ctrl) and SCD mice. uCT and histomorp...

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Literature Corpus work
847cf6c5-1b49-5202-abf1-da8a38a4a6f6
DOI
10.21203/rs.3.rs-1778156/v1
Open publication

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