Article

Nitazoxanide controls virus viability through its impact on membrane bioenergetics

2024-02-20

Abstract excerpt

<title>Abstract</title> <p>Viruses are dependent on cellular energy metabolism for their replication, and the drug nitazoxanide (Alinia) was shown to interfere with both processes. Nitazoxanide is an uncoupler of mitochondrial oxidative phosphorylation (OXPHOS). Our hypothesis was that mitochondrial uncoupling underlies the antiviral effects of nitazoxanide. Tizoxanide (the active metabolite of nitazoxanide), its...

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Identifiers and source

Literature Corpus work: 8463a290-d7e2-5a8e-85a6-efae2da6615a
DOI: 10.21203/rs.3.rs-3910330/v1

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