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Mitochondrial Toxicity of Indinavir, Stavudine and Zidovudine Involves Multiple Cellular Targets in white and brown adipocytes

1 Aug 2007

Abstract excerpt

OBJECTIVE: To evaluate the mechanisms of mitochondrial toxicity associated with antiretroviral treatment. METHODS: 3T3-F442A white and T37i brown adipocytes were exposed to stavudine (10 microM), zidovudine (1 microM) and indinavir (10 microM), alone or in combination. Adipocyte fat content was measured with Oil Red 0 staining. Quantification of mRNA levels and of mitochondrial DNA content used PCR-based...

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PMID: 17926646
DOI: 10.1177/135965350701200610

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