Article

G4-Selective Ligand Induced Autophagy

2021-09-27

Abstract excerpt

G-quadruplex (G4) structures have emerged as singular therapeutic targets for cancer and neurodegeneration. Autophagy is a housekeeping cellular homeostatic mechanism and deregulation of autophagy is common in cancer and in neurodegenerative diseases. In this study, we identified the presence of 46 putative G4 sequences in the MTOR gene by use of QGRS mapper tool. We sought to connect these putative G4 sequences t...

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Literature Corpus work: 84523d2d-d785-5d5d-91a2-eed928287f21
DOI: 10.1101/2021.09.26.461892

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