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Article

Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes.

Journal of medicinal chemistry - 8 Feb 2024

Li Mao-Lin, Dai Le-Tian, Gao Zhuo-Yu, Yan Jia-Tong, Xu Shu-Min, Tan Jia-Heng, Huang Zhi-Shu, Chen Shuo-Bin, Chen Xiu-Cai

Abstract excerpt

Hyperactivated KRAS mutations fuel tumorigenesis and represent attractive targets for cancer treatment. While covalent inhibitors have shown clinical benefits against the KRASG12C mutant, advancements for non-G12C mutants remain limited, highlighting the urgent demand for pan-KRAS inhibitors. RNA G-quadruplexes (rG4s) in the 5'-untranslated region of KRAS mRNA can regulate KRAS translation, making them promising...

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Identifiers

PMID: 38272464
DOI: 10.1021/acs.jmedchem.3c01773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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