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Article

Non-Photoinduced Biological Properties of Verteporfin

16 Mar 2016

Abstract excerpt

BACKGROUND: Verteporfin is a porphyrinic photosensitizer clinically used for the photodynamic treatment of age-related macular degeneration. It has been identified almost simultaneously as a YAP/TEAD and an autophagosome inhibitor. Over the last few years, YAP (TAZ), the downstream effectors of the Hippo pathway, have emerged as promising anticancer targets, as shown by several experimental lines of evidence,...

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PMID: 26980565
DOI: 10.2174/0929867323666160316125048

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