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Article

Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.

EBioMedicine - 1 Sept 2017

Wang Li-Chao, Liao Li-Xi, Lv Hai-Ning, Liu Dan, Dong Wei, Zhu Jian, Chen Jin-Feng, Shi Meng-Ling, Fu Ge, Song Xiao-Min, Jiang Yong, Zeng Ke-Wu, Tu Peng-Fei

Abstract excerpt

Heat shock protein 70 (Hsp70) is widely involved in immune disorders, making it as an attractive drug target for inflammation diseases. Nonselective induction of Hsp70 upregulation for inflammation therapy could cause extensive interference in inflammation-unrelated protein functions, potentially resulting in side effects. Nevertheless, direct pharmacological activation of Hsp70 via targeting specific functional...

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Identifiers

PMID: 28807514
DOI: 10.1016/j.ebiom.2017.08.011
PMCID: PMC5605382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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