Article

Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders

2020-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unraveled Beclin-1 as druggable candidate for therapy of hyperammonemia. Next, we investigated efficacy of cell penetrating autophagy inducing Tat-Beclin-1 (TB-1) peptid...

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Literature Corpus work: 83f46c0a-208f-5c3a-aa3b-3f6784e92772
DOI: 10.1101/2020.07.22.216382

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