Article

The Mechanism of Hyperammonemia Triggered by Corticosteroid Administration in Late-Onset Ornithine Transcarbamylase Deficiency

2021-11-29

Abstract excerpt

<title>Abstract</title> <p> Background: Ornithine transcarbamylase deficiency (OTCD) is most popular among urea cycle disorders (UCDs), defined by the loss of function in any of the enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, including OTCD patients, is well known to induce life-threatening hyperammonemia. The mechanism has been considered nitrogen overload due to the cata...

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Literature Corpus work: ce04c92b-1b27-5b3a-9314-42012b2ad577
DOI: 10.21203/rs.3.rs-1089064/v1

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