Article

A ratio-based framework using Quartet reference materials for integrating long- and short-read RNA-seq

2025-09-17

Abstract excerpt

Long-read RNA sequencing (lrRNA-seq) enables full-length transcript profiling but is confounded by technical batch effects that compromise quantification and prevent data integration across platforms, protocols, and laboratories. The lack of a transcriptome-wide biological ground truth has hindered objective benchmarking. To address these dual challenges, we leveraged certified Quartet reference materials to gener...

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Literature Corpus work: 83ef174a-a249-5f06-9897-2ed6db94a644
DOI: 10.1101/2025.09.15.676287

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