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Fluorescence Lifetime Imaging Microscopy Reveals Metabolic Changes in Aging Lacrimal Gland Suggestive of Increased Inflammation and Oxidative Stress

2025-10-17

Abstract excerpt

Although dry eye disease (DED) is common with age, the cellular and metabolic changes in the lacrimal gland (LG) that contribute to this condition are not fully un-derstood. Here, we applied fluorescence lifetime imaging microscopy (FLIM) to ex-amine metabolic alterations in LG tissue from aged (20-22 months) female C57BL/6J mice, a model of age-related DED, versus young (~3 months) C57BL/6J mice. Phasor analysis...

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Literature Corpus work
83da9810-9a29-5a0f-a444-c1af8f6673b5
DOI
10.20944/preprints202510.1342.v1
Open publication

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Fluorescence Lifetime Imaging Microscopy Reveals Metabolic Changes in Aging Lacrimal Gland Suggestive of Increased Inflammation and Oxidative StressDOI 10.20944/preprints202510.1342.v1
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