Article

A novel fully-human potency-matched dual cytokine-antibody fusion protein targets carbonic anhydrase IX in renal cell carcinomas

2019-08-22

Abstract excerpt

Certain cytokines synergize in activating anti-cancer immunity at the site of disease and it may be desirable to generate biopharmaceutical agents, capable of simultaneous delivery of cytokine pairs to the tumor. In this article, we have described the cloning, expression and characterization of IL2-XE114-TNF mut , a dual-cytokine biopharmaceutical featuring the sequential fusion of interleukin-2 (IL2) with the XE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 839ab19b-e654-5916-a110-d1fbdffc00b8
DOI: 10.1101/744029

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel fully-human potency-matched dual cytokine-antibody fusion protein targets carbonic anhydrase IX in renal cell carcinomasDOI 10.1101/744029Read

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cellsSemantic proximity Read

Low-dose cytokine immunotherapy of solid cancers enabled by phagocytic-competent protein co-crystalsSemantic proximity Read

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formatsSemantic proximity Read

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.Semantic proximity Read

A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.Semantic proximity Read

Combining DNA Vaccine and AIM2 in H1 Nanoparticles Exert Anti-Renal Carcinoma Effects via Enhancing Tumor-Specific Multi-functional CD8+ T-cell ResponsesSemantic proximity Read

Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy.Semantic proximity Read

Towards Effective CAIX-targeted Radionuclide and Checkpoint Inhibition Combination Therapy for Advanced Clear Cell Renal Cell CarcinomaSemantic proximity Read

Catalytic activity of anin vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion proteinSemantic proximity Read

Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses.Semantic proximity Read

Phase 2 studies of sunitinib and AG013736 in patients with cytokine-refractory renal cell carcinoma.Semantic proximity Read

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.Semantic proximity Read